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This technical report summarizes the methodology and data sources used to develop a state-based modeling framework intended to be used to estimate the costs, and the economic, public health, and climate benefits of state-level policy actions requiring manufacturers to increase the share of new medium- and heavy-duty vehicles that are no- and low-emissions. The modeling framework includes all on-road vehicles of more than 8,500 pounds gross vehicle weight, encompassing vehicle weight classes from Class 2b though Class 8 and covering a diverse set of mostly commercial vehicles including heavy-duty pickups and vans; school and transit buses; sanitation, construction, and other types of work trucks; and tractor-trailers that weigh more than 80,000 pounds when loaded. Detailed results from using the framework to estimate net benefits of specific policy scenarios in various states will be published in separate reports.